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Know about breast cancer ...

Sometimes, a diagnosis of breast cancer is made after the onset of signs and symptoms. But many women with breast cancer have no symptoms.For this reason, regular breast cancer screening is very important ...


Breast cancer is the most common malignancy and the leading cause of death among women, starting in the breast tissue and can affect both men and women.

The disease accounts for about 25 percent of all malignancies and causes 3.3 deaths per 100,000 people. In Tehran, the prevalence of this disease is about 25.5% of all cancers.

Sometimes, a diagnosis of breast cancer is made after the onset of signs and symptoms. But many women with breast cancer have no symptoms. For this reason, regular breast cancer screening is very important.


Signs and symptoms of breast cancer

Some of the symptoms include:

• Discharge from the breast

• Nipple indentation

• Changes in the skin of the breast and symptoms such as redness, changes in the texture or wrinkling of the skin of the breast


Cause of breast cancer

Starting menstruation at an early age or menopause at an older age increases the risk of breast cancer. Women who use contraception after the age of 30 and do not have children are more likely to develop breast cancer. Taking birth control pills also increases the chances of getting this cancer.

Life style

• Obesity, overweight or eating fatty foods increase the risk of breast cancer.

• People who drink a lot of alcohol are more likely to get breast cancer.

• Regular exercise is one of the measures that reduces the risk of breast cancer.

• Environmental factors: People who receive radiotherapy in the upper body are more likely to develop breast cancer.

• Genetic causes and genetic mutations and hormonal causes.



The role of mammography in the early detection of breast cancer:


Mammography is a type of X-ray that is used to diagnose breast disease. Using mammography as a screening method, breast cancer can be diagnosed before it becomes a palpable mass.


Mammography is also necessary in healthy people, and the recommendation to have a mammogram in a woman does not mean that she has cancer.

What should be noted is that the risks of X-rays hitting the breast in this way are very small and can be ignored. In fact, the benefits of early detection with this method far outweigh the potential risks, because on the one hand, the amount of X-rays that penetrate the tissues is very small, and on the other hand, the amount of radiation needed to cause cancer is much higher than the radiation. It is irradiated to the breast by mammography.


Who should have MRI screening in addition to mammography?


In certain population of women, such as:

• Women who have a known BRCA-1 or BRCA-2 mutation.

• People with a family history of breast or ovarian cancer.

• People who have had breast cancer before are known to have lobular cancer and have received radiation therapy.

New methods of laboratory diagnosis for different types of breast cancer:

Early detection of breast cancer will make its treatment easier and more successful and will play an important role in managing the disease to cause fewer complications on other organs of the body due to tumor growth, which improves the quality of life and longevity of patients.

One of the causes of cancer is proto-oncogenes, which are converted to oncogenes by various processes, including mutations and gene amplification, thereby activating or over-producing gene products.

Different genes are involved in the development and progression of breast cancer. Tumor development and growth in a group of patients is dependent on HER2 gene amplification. Among new patients, 15 to 20% belong to this group. Of course, mutations in this gene can also cause other cancers, such as ovarian, gastric and uterine cancers.


The HER2 test is performed on patients with breast cancer to determine the progression of the disease and to determine the appropriateness of herceptin therapy.


It is important to note that herceptin therapy should only be given to HER2-positive patients because, in addition to being expensive, it can also be associated with heart damage. For HER2-negative tumors, the use of herceptin is not only beneficial but may also be harmful. The HER2 test is usually done on a biopsy specimen.



HER2: Human epidermal growth factor receptor 2

Early detection of breast cancer not only increases the chances of treatment, but also prevents its psychological, familial and social complications.

One way to diagnose breast cancer early is to have a breast self-examination or breast exam.


What is a breast self-examination?

Breast self-examination is the examination of the breast by the person herself. This examination is applicable to any woman and at any age. With a monthly breast exam, you will become familiar with the characteristics of your breast and you will be able to detect any changes in the early stages.

It is important to note that a monthly checkup can not replace a clinical checkup by a doctor or mammogram and is actually helpful in the interval between medical visits. Therefore, regular examinations at intervals of 6-12 months by a doctor and mammography according to the doctor should be done along with breast self-examination.


How to do a breast self-examination?

Breast self-examination should be done every month on a certain date and in a specific way.


Breast self-examination time:

Women can have a breast self-examination from the age of 20.


The best time to have a monthly checkup is 2-3 days after your period. In other words, about the ninth or tenth day of menstruation is a good time to get tested. At this time, the breasts are the least sensitive and heavy, so the examination is easier and the result of the examination is more accurate.

In breastfeeding women, it is best to have an examination after breastfeeding and emptying the breast. Also, if you are taking hormonal treatments, it is best to talk to your doctor about when to do a self-examination.


How to do a breast self-examination:

Breast self-examination involves two steps: looking and touching.


• looking

In some cases, breast diseases, especially breast cancers, can cause changes in the appearance of the breast that can be detected by looking at the breasts. Therefore, you need to be familiar with the appearance of your breasts to be able to detect any possible changes in them.


Looking involves several steps:

1- Hang your hands on either side of your body and look at your breasts.

2- Raise your hands flat from the side of your head.

3- Bend your arms at the elbows and press against your waist.

4- Stretch your arms straight forward and lean forward slightly.

Date Release : 2021/08/23
کد : 20015
visits: 35